The IMBM is recognised as one of the leading research units at the UWC. The Institute focuses on recent advances in (meta)genomics and bioinformatics for the identification of genes or biosynthetic pathways and their heterologous expression to produce natural and novel high-value biochemicals. As one of the five Nodes of the CSIR/TIA/DSI Industrial Biocatalysis Hub, the IMBM develops selected technologies in biocatalysis for potential industrial assimilation.
The IMBM invites applications for a one-year Postdoctoral Fellowship to advance one of the selected technologies i.e. further process development for the production of two patented biosurfactants, a lyso-ornithine lipid (LOL) which is produced in E. coli and a ornithine lipid (OL) which is produced in P. putida. The position is available for 2024.
The project will focus on the further improvement of the LOL and OL production strains through e.g. further genetic modification and/or co-expression of selected genes that may relieve metabolic bottlenecks, assessing fermentation parameters that may influence production, as well as optimisation of down-stream processing at laboratory scale.
• A PhD degree in a foundational discipline relevant to the topic, complete in the past five years,
• a minimum of 2 years post-PhD experience in (bio)chemistry with a focus on metabolism, strong project management and trouble-shooting skills, and
• a South African citizen.
Experience in cloning, heterologous expression and other genetic engineering strategies, and a strong publication record will be considered as advantages.